Meniere et virus

Pasien penyakit Meniere cenderung sulit mendengar suara dalam frekuensi rendah. Oleh karena itu, tes pendengaran atau audiometri dilakukan untuk mengetahui kemampuan pasien mendengar.

Pasien akan diminta untuk mendengar suara dalam nada dan volume yang bervariasi. Hasil tes akan menentukan apakah pasien mengalami gangguan pendengaran, baik pada satu telinga maupun keduanya. Salah satu fungsi dari telinga bagian dalam adalah mengatur keseimbangan tubuh. Oleh karena itu, pada pasien penyakit Meniere, gangguan pada keseimbangan tubuh bisa terjadi.

Meski jarang dilakukan, pemindaian seperti MRI atau CT scan otak dapat digunakan untuk menyingkirkan kemungkinan gejala penyakit Meniere disebabkan oleh kondisi lain, seperti tumor otak atau multiple sclerosis.

Penyakit Meniere merupakan kondisi kronis yang belum dapat disembuhkan secara total. Akan tetapi, beberapa penanganan dapat dilakukan untuk meringankan gejalanya. Confirming the DNA sequence alteration by traditional molecular techniques, linkage analysis in selected pedigrees, and replication of the association in at least a second population is essential to confirm any preliminary finding. National Center for Biotechnology Information , U.

Journal List Appl Clin Genet v. Appl Clin Genet. Published online Jan 8. Author information Copyright and License information Disclaimer. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

This article has been cited by other articles in PMC. Limits to a successful genetic approach to MD In an effort to develop uniform reporting criteria for MD, the American Academy of Otolaryngology-Head and Neck Surgery Committee on Hearing and Equilibrium published guidelines for diagnosing this entity in Rationale for genetic suspicion for MD There are several characteristics of MD that support a genetic background.

Open in a separate window. Linkage studies Linkage analysis relies on evaluation of genomic markers to identify the region of the genome that segregates with the disease. Chromosome 12 Klar et al 61 studied a large Swedish family segregating for MD for linkage to loci in known familial forms of cochleovestibular dysfunction using a genome wide set of microsatellite markers. Candidate genes association studies In this approach, genes hypothesized to be involved in MD are screened in affected individuals.

Genes involved in ionic composition or water transport Aquaporin Some authors focused on mutations in aquaporin AQP , a transmembrane protein expressed in the endolymphatic sac that transports water and other solutes through the cell membrane. Interleukin-1 Furuta et al 79 documented the association of interleukin-1 gene IL1 polymorphism to both MD and sudden sensorineural hearing loss. Conclusion Based on the published reports analyzed in this review, we can conclude that no convincing evidence for an association with a specific gene has been found, at present.

In fact, all the findings in literature indicate a genetic heterogeneity. Acknowledgments The authors want to thank Professor Nicola Perrotti for his precious contribution. Footnotes Disclosure The authors have no conflicts of interest to disclose. References 1. Otolaryngol Head Neck Surg. Arch Otolaryngol. Acta Otolaryngol. Otol Neurotol. Clemmens C, Ruckenstein M.

J Laryngol Otol. Am J Otolaryngol. Vrabec JT. Otolaryngol Clin North Am. Genetic disorders of the vestibular system. Clin Genet. Am J Audiol. No authors listed. Audiol Neurootol. Hallpike C, Cairns H. Wangemann P. K1 cycling and the endocochlear potential. Hear Res. J Natl Med Assoc. Efficacy of antimigrainous therapy in the treatment of migraine-associated dizziness. Am J Otol. Spruance SL. The natural history of recurrent oral-facial herpes simplex virus infection. Semin Dermatol. Clin Exp Immunol.

Audiol Neurotol. Ann Otol Rhinol Laryngol. BMC Med Genet. Associative analyses of any viral species not aforementioned were precluded by limited data, and thus potential associations between other viral species and MD, especially other than Herpesviridae, are yet to be characterised.

Overall, we have found a small association between CMV-infection and MD, however it is to be determined for what sub-groups of MD this finding may be relevant, and ideally the reported association remains would be reproduced by a greater volume of higher quality evidence. Purchase access. Rent article Rent this article from DeepDyve.

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